AI Article Synopsis
Article Abstract
We characterized a zebrafish (Danio rerio) anterior gradient 2 homologue (agr2) gene. agr2 contains an open reading frame of 513bp encoding 171 amino acids. Deduced amino acid sequence comparison showed that the zebrafish agr2 protein shares high (80-89%) amino acid sequence similarity with those homologues of anterior gradient 2 (HAGR2, MAgr2, Tagr2, and Sagr2) from the human, mouse, pufferfish, and Atlantic salmon, while sharing less (67-71%) sequence similarity with those anterior gradient 2 genes (XAG-2, XAG-1, XAgr2, MAgr3, and HAGR3) from Xenopus laevis, mouse, and human. Both phylogenetic and syntenic analyses indicate that zebrafish agr2 is the orthologue of human AGR2 and mouse Agr2 genes. Whole-mount in situ hybridization indicated that zebrafish agr2 is expressed in most organs, such as epidermis, olfactory bulbs, otic vesicles, pharynx, esophagus, pneumatic duct, swim bladder, and intestine, which contain mucus-secreting cells. Moreover, semi-quantitative RT-PCR demonstrated agr2 is expressed in the gill, pharynx/esophagus, swim bladder/pneumatic duct, and intestine in the adult fish. In contrast, Xenopus anterior gradient 2 homologues are mainly expressed in ectoderm-derived organs including the cement gland and otic vesicles, while human and mouse anterior gradient 2 orthologues are mainly distributed in endoderm-derived organs including the trachea, lungs, stomach, intestines, and colon.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.modgep.2006.11.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-organization from organs to embryoids by activin in early amphibian development.
Cells Dev
January 2025
Department of Agri-Production Sciences, College of Agriculture, Tamagawa University, Tokyo, Japan.
Embryonic development is a complex self-organizing process orchestrated by a series of regulatory events at the molecular and cellular levels, resulting in the formation of a fully functional organism. This review focuses on activin protein as a mesoderm-inducing factor and the self-organizing properties it confers. Activin has been detected in both unfertilized eggs and embryos, suggesting its involvement in early developmental processes.
View Article and Find Full Text PDFDefining "Giant" Mediastinal Tumors: Proposal of a New Clinical-Radiological Classification and Case Report.
Diagnostics (Basel)
January 2025
Niculae Stancioiu Heart Institute, Calea Motilor 19-21, 400001 Cluj-Napoca, Romania.
Mediastinal tumors, regardless of their location, can grow to significant sizes, causing compression-related symptoms. The term "giant" mediastinal tumor is inconsistently defined in the literature. This study presents a new clinical-radiological classification (CRC) for mediastinal tumors and evaluates its applicability through a systematic review and a detailed case analysis of a giant thymolipoma.
View Article and Find Full Text PDFDirect Axillary Artery Cannulation as Standard Perfusion Strategy in Minimally Invasive Coronary Artery Bypass Grafting.
J Cardiovasc Dev Dis
January 2025
Department of Cardiothoracic Surgery, Heart-Thorax Center, Klinikum Fulda, University Medicine Marburg, Campus Fulda, 36043 Fulda, Germany.
Objective: Cardiopulmonary bypass (CPB) via the right axillary artery (RAA) has become an alternative perfusion strategy, especially in complex aortic procedures. This study delineates our technique and outcome with direct axillary cannulation utilizing the Seldinger technique, which we adopted as the standard perfusion strategy in the sternum-sparing minimally invasive total coronary revascularization via left anterior thoracotomy (TCRAT) using CPB.
Methods: From November 2019 to December 2023, a total of 413 consecutive patients underwent nonemergent isolated coronary artery bypass grafting (CABG) via left anterior minithoracotomy on CPB with peripheral cannulation via the RAA and cardioplegic cardiac arrest, using this technique as a default strategy in the daily routine.
Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.
Biomater Res
January 2025
Academy of Orthopedics, Guangdong Province, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510665, P. R. China.
Tendon/ligament-bone junctions (T/LBJs) are susceptible to damage during exercise, resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate hierarchical structure hinders self-regeneration. Multiphasic strategies have been explored to fuel heterogeneous tissue regeneration and integration. This review summarizes current multiphasic approaches for rejuvenating functional gradients in T/LBJ healing.
View Article and Find Full Text PDFImpact of A1 segment asymmetry on hemodynamic conditions around the circle of Willis and anterior communicating artery aneurysm formation.
Front Neurol
January 2025
Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Background: This study aims to investigate how A1 segment asymmetry-also known as A1 dominancy-influences the development of the anterior communicating artery aneurysm (AcomA) as it affects hemodynamic conditions within the circle of Willis (COW). Using time-of-flight magnetic resonance angiography (TOF-MRA), the research introduces a novel approach to assessing shear stress in A1 segments to uncover the hemodynamic factors contributing to AcomA formation.
Method: An observational study was conducted over 6 years at a tertiary university hospital's outpatient clinic.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!