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Cytotoxic farnesyl glycosides from Pittosporum pancheri. | LitMetric
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Cytotoxic farnesyl glycosides from Pittosporum pancheri.

Véronique Eparvier Odile Thoison Hadjira Bousserouel Françoise Guéritte Thierry Sévenet Marc Litaudon

Phytochemistry

Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

Published: March 2007

Bioassay guided purification of the ethanolic extract of the bark of New Caledonian Pittosporum pancheri Brongn. and Gris (Pittosporaceae) led to the isolation and characterization of two new farnesyl monoglycosides, pancherins A and B. The structure of these compounds were determined on the basis of spectroscopic studies. The new compounds displayed a significant activity in the in vitro cytotoxic assay against KB cancer cell line, and pancherin A inhibits weakly farnesyl protein transferase.

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http://dx.doi.org/10.1016/j.phytochem.2006.11.008DOI Listing

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