Microtubule capture: a concerted effort.

Cell

Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, A2-168, Seattle, WA 98109, USA.

Published: December 2006

AI Article Synopsis

Article Abstract

Kinetochores direct attachment of chromosomes to microtubules of the mitotic spindle during cell division. Three recent studies in Cell, including one in this issue, reveal important new roles for two kinetochore protein complexes-Ndc80 and INCENP-Survivin-in establishing the correct attachment of chromosomes to spindle microtubules (Cheeseman et al., 2006, DeLuca et al., 2006 and Sandall et al., 2006).

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2006.11.032DOI Listing

Publication Analysis

Top Keywords

attachment chromosomes
8
microtubule capture
4
capture concerted
4
concerted effort
4
effort kinetochores
4
kinetochores direct
4
direct attachment
4
chromosomes microtubules
4
microtubules mitotic
4
mitotic spindle
4

Similar Publications

The spread of antibiotic resistance genes (ARGs) in rural wastewater threatens both ecological environment and human health. Earthworm ecological filters (EEFs) represent a green technology for rural sewage treatment. However, their effectiveness in removing ARGs remains a significant challenge.

View Article and Find Full Text PDF

Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics.

Eur J Med Chem

January 2025

Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:

NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.

View Article and Find Full Text PDF

Organization of the chromosomal passenger complex clusters at inner centromeres in mitosis.

Curr Opin Cell Biol

January 2025

Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan; Department of JFCR Cancer Biology, Institute of Science Tokyo, Tokyo, Japan. Electronic address:

Stable transmission of the genome during cell division is crucial for all life forms and is universally achieved by Aurora B-mediated error correction of the kinetochore-microtubule attachments. Aurora B is the enzymatic subunit of the tetrameric protein complex called the chromosomal passenger complex (CPC), and its centromeric enrichment is required for Aurora B to ensure accurate chromosome segregation. How cells enrich the CPC at centromeres is therefore an outstanding question to be elucidated.

View Article and Find Full Text PDF

During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability. Here, we show that shugoshin (Sgo1), a conserved tension-sensing protein, ensures the maintenance of SAC signals in response to unattached kinetochores during mitosis in a basidiomycete budding yeast Cryptococcus neoformans.

View Article and Find Full Text PDF

Close cooperation between Semi1 and Semi2 proteins is essential for pronuclear positioning in .

Mol Biol Cell

January 2025

Department of Biosciences, College of Humanities and Sciences, Nihon University, Tokyo 156-8550, Japan.

During sexual reproduction in the ciliate , meiosis occurs in the germline micronucleus, resulting in the formation of four haploid micronuclei. Of these, only one is selected to evade autophagy, and subsequently migrates to the membrane junction with the partner cell for reciprocal pronuclear exchange. We previously demonstrated that the transmembrane protein Semi1 is essential for this nuclear migration.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!