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Local and systemic biodistribution of a small-molecule radiopharmaceutical probe after transcatheter embolization and intra-arterial delivery in a porcine orthotopic renal tumor model.
Nucl Med Commun
February 2025
Department of Radiology, Netherlands Cancer Institute- Antoni van Leeuwenhoekziekenhuis, Amsterdam, The Netherlands.
Background: Small-molecule biomacromolecules target tumor-specific antigens. They are employed as theranostic agents for imaging and treatment. Intravenous small-molecule radioligands exhibit rapid tumor uptake and excretion.
View Article and Find Full Text PDFMetabolism and Excretion of [C]Mobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects.
Drug Metab Dispos
September 2024
Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc., Cambridge, Massachusetts (H.C., A.S., S.K., R.G., S.P., L.C., Y.L., S.K.C., S.X.Z.); and Quantitative Clinical Pharmacology, Takeda Development Center Americas, Inc., Cambridge, Massachusetts (S.Z.)
Mobocertinib (formerly known as TAK-788) is a targeted covalent tyrosine kinase inhibitor of epidermal growth factor receptor with exon 20 insertion mutations. This article describes the metabolism and excretion of mobocertinib in healthy male subjects after a single oral administration of [C]mobocertinib. Mobocertinib-related materials were highly covalently bound to plasma proteins such as human serum albumin.
View Article and Find Full Text PDFIntra-arterial PRRT with Lu-177 DOTATATE in Liver-dominant Metastatic Neuroendocrine Tumors: Early Assessment of Efficacy and Toxicity.
Indian J Nucl Med
May 2024
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Purpose: We proposed to administer Lu-177-DOTATATE in intra-arterial (IA) mode for higher first-pass localization to somatostatin receptors, higher residence time in liver metastases, and more radiation to tumor. This study aimed at assessing early hematological, renal and hepatotoxicity; and objective response to IA peptide receptor radionuclide therapy (PRRT).
Materials And Methods: Fourteen patients (4 females and 10 males) were prospectively assessed.
Noninvasive measurement of tracer extraction efficiency in tissue, illustrated with Tc-99m-MAG3.
Nucl Med Commun
June 2024
Department of Nuclear Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Objective: The aim of this study is to develop a noninvasive technique for measuring tissue tracer extraction efficiency ( E ) and illustrate it for Tc-99m-mercaptoacetyltriglycine (MAG3) and kidney.
Methods: E was measured in 10 patients with normal MAG3 renography. E is the ratio of tissue clearance-to-blood flow ( Ki/F ).
Quantitative analysis of abdominal aortic blood flow by Tc-DTPA renal scintigraphy in patients with heart failure.
Ann Nucl Med
June 2024
Heart Failure Center, The First Hospital of Hebei Medical University, Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, Hebei, China.
Objective: This study aimed to explore the characteristics of abdominal aortic blood flow in patients with heart failure (HF) using Tc-diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy. We investigated the ability of renal scintigraphy to measure the cardiopulmonary transit time and assessed whether the time-to-peak of the abdominal aorta (TTPa) can distinguish between individuals with and without HF.
Methods: We conducted a retrospective study that included 304 and 37 patients with and without HF (controls), respectively.
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