The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2006.09.072DOI Listing

Publication Analysis

Top Keywords

analogues 2-crotonyloxymethyl-4r5r6r-456-trihydroxycyclohex-2-enone
4
2-crotonyloxymethyl-4r5r6r-456-trihydroxycyclohex-2-enone cotc
4
cotc anti-tumor
4
anti-tumor properties
4
properties syntheses
4
syntheses three
4
three novel
4
novel analogues
4
analogues naturally
4
naturally occurring
4

Similar Publications

A rare glisoprenin analogue from an endophytic fungus sp. F1.

Nat Prod Res

January 2025

Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, People's Republic of China.

Glisoprenins are unique fungal polyisoprenepolyols with nine isoprene units from spp. Herein, glisoprenin G (), a new member of glisoprenins group, along with a biosynthetically related known analogue glisoprenin F (), were isolated and identified from an endophytic fungus, sp. F1, harboured in the roots of the Chinese medicinal plant .

View Article and Find Full Text PDF

Quinolone antibiotics are a crucial class of synthetic antibacterial agents, widely utilized due to their broad spectrum of antibacterial activity. Due to the development of antimicrobial resistance, the potency of quinolone drugs decreased. Many conventional methods have been developed to elevate amination rate and to improve yield.

View Article and Find Full Text PDF

This was an original article, mainly explored the effect of applying airbag bionic midwifery technology in vaginal delivery of scarred uterus pregnancy. Sixty patients were chosen, and divided into an intervention group (IG) and a control group (CG). The results showed that in contrast to the CG, the IG had shorter first, second and total stages of labor (P<0.

View Article and Find Full Text PDF

Background: Studies are still limited on the isolated effect of retear after arthroscopic rotator cuff repair (ARCR) on functional outcomes after the midterm period.

Purpose: To assess the effect of retear at midterm follow-up after ARCR and to identify factors associated with the need for revision surgery.

Study Design: Cohort study; Level of evidence, 3.

View Article and Find Full Text PDF

Surgical frequency analysis of patients clustered according to postoperative pain trajectory: a retrospective study.

Sci Rep

January 2025

Department of Dental Anesthesiology, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Oropharyngeal and orthognathic surgeries cause more postoperative pain than simple dental procedures. The lack of detailed pain pattern analysis after dental surgeries makes pain management challenging. We assessed postoperative pain patterns in patients undergoing various dental surgeries, categorized based on changing pain levels, and identified the most frequent surgical procedures within each pain pattern cluster.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!