AI Article Synopsis
- The study investigates graft vascularization using indocyanine green angiography after pterygium surgery with two types of grafts: limbal-conjunctival autograft transplantation (LCAT) and amniotic membrane transplantation (AMT).
- After evaluating anterior segment ICGA findings at multiple time points, results showed early vascularization in LCAT grafts by day 7, while AMT grafts exhibited no vascularization throughout the studied period.
- The findings suggest that LCAT provides better early graft health, while AMT may experience delayed vascularization, possibly affecting graft perfusion and recurrence of pterygium, indicating a need for further research.
Article Abstract
Purpose: To monitor the development of graft vascularization by indocyanine green angiography (ICGA) after pterygium excision with limbal-conjunctival autograft transplantation (LCAT) and amniotic membrane transplantation (AMT).
Design: Randomized prospective interventional case series.
Methods: Anterior segment ICGA findings at one, seven, and 30 days after surgery were evaluated in eyes with primary pterygium treated by excision and LCAT (14 eyes of 14 patients) or AMT (13 eyes of 13 patients), and the results for graft vascularization were compared.
Results: All conjunctival autografts showed early vascularization from underlying episcleral vascular bed as multiple hyperfluorescent foci at the graft margin on postoperative day 7; graft vascularization was complete on postoperative day 30. In contrast, all grafts in AMT group showed no graft vascularization at any stage after pterygium surgery. This delay of vascularization with AMT persisted until one month after surgery.
Conclusions: Anterior segment ICGA is useful to monitor graft vascularization after pterygium surgery. Graft health after LCAT may be demonstrated by early graft vascularization and perfusion; however, there is a delay in graft vascularization after AMT that may be related to the antiangiogenic effects of the membrane. Further study is needed to demonstrate the relationship between this delay of graft perfusion and early postoperative pterygium recurrence.
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| http://dx.doi.org/10.1016/j.ajo.2006.10.032 | DOI Listing |
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