AI Article Synopsis
- The third-stage larvae (L3) of the parasitic nematode Anisakis simplex can trigger severe allergic reactions in humans who ingest them.
- A review of experimental infections in animals provided insights into the immune responses against the excretory-secretory products of A. simplex L3.
- This model can be useful for future research on the immune mechanisms and allergies related to anisakiasis in humans.
Article Abstract
The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559135 | PMC |
| http://dx.doi.org/10.3347/kjp.2006.44.4.271 | DOI Listing |
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