AI Article Synopsis
- The study focuses on creating new cyclic pentapeptides that have a specific structural bias, featuring the RGD sequence and based on a tetrahydroazoninone framework.
- These peptides show significant activity towards the integrin alphaVbeta3, which is important for various biological processes.
- They also demonstrate a notable selectivity over integrin alphaVbeta5, suggesting potential for targeted therapeutic applications.
Article Abstract
The synthesis of new conformationally biased cyclic pentapeptides, incorporating the RGD sequence, and built around a tetrahydroazoninone scaffold, is reported. They exhibit interesting activity towards integrin alphaVbeta3 and a remarkable selectivity in comparison with integrin alphaVbeta5.
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| http://dx.doi.org/10.1016/j.bmcl.2006.11.085 | DOI Listing |
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