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Of nanobacteria, nanoparticles, biofilms and their role in health and disease: facts, fancy and future.
Nanomedicine (Lond)
April 2014
Laboratory of Nanomaterials, Chang Gung University, Gueishan, Taoyuan 333, Taiwan.
Nanobacteria have been at the center of a major scientific controversy in recent years owing to claims that they represent not only the smallest living microorganisms on earth but also new emerging pathogens associated with several human diseases. We and others have carefully examined these claims and concluded that nanobacteria are in fact nonliving mineralo-organic nanoparticles (NPs) that form spontaneously in body fluids. We have shown that these mineral particles possess intriguing biomimetic properties that include the formation of cell- and tissue-like morphologies and the possibility to grow, proliferate and propagate by subculture.
View Article and Find Full Text PDFBiomineralization at pathological extraosseous sites (i.e. vasculature and soft tissues) is associated with increased morbidity and mortality.
View Article and Find Full Text PDFPutative nanobacteria represent physiological remnants and culture by-products of normal calcium homeostasis.
PLoS One
April 2009
Laboratory of Nanomaterials, Chang Gung University, Gueishan, Taiwan, Republic of China.
Putative living entities called nanobacteria (NB) are unusual for their small sizes (50-500 nm), pleomorphic nature, and accumulation of hydroxyapatite (HAP), and have been implicated in numerous diseases involving extraskeletal calcification. By adding precipitating ions to cell culture medium containing serum, mineral nanoparticles are generated that are morphologically and chemically identical to the so-called NB. These nanoparticles are shown here to be formed of amorphous mineral complexes containing calcium as well as other ions like carbonate, which then rapidly acquire phosphate, forming HAP.
View Article and Find Full Text PDFPurported nanobacteria in human blood as calcium carbonate nanoparticles.
Proc Natl Acad Sci U S A
April 2008
Department of Biochemistry and Cellular Molecular Biology, Chang Gung University, 259 Wen-Hua First Road, Kwei-Shan, Tao-Yuan 333, Taiwan, Republic of China.
Recent evidence suggests a role for nanobacteria in a growing number of human diseases, including renal stone formation, cardiovascular diseases, and cancer. This large body of research studies promotes the view that nanobacteria are not only alive but that they are associated with disease pathogenesis. However, it is still unclear whether they represent novel life forms, overlooked nanometer-size bacteria, or some other primitive self-replicating microorganisms.
View Article and Find Full Text PDFIs there any relation of nanobacteria with periodontal diseases?
Med Hypotheses
April 2008
Department of Periodontology, Atatürk University, Faculty of Dentistry, 25240 Erzurum, Turkey.
Periodontal diseases, including gingivitis and periodontitis, have been described as inflammation of the supporting tissues of the teeth. The main cause of periodontal disease is dental plaque. If dental plaque is not eliminated of dental surface, mineralized dental plaque (calculus) occur.
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