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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders.

Respir Res

January 2025

Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, School of Medicine, Wayne State University, 275 E Hancock St, Rm 195, Detroit, MI, 48201, USA.

Current fetal alcohol spectrum disorders (FASD) studies primarily focus on alcohol's actions on the fetal brain although respiratory infections are a leading cause of morbidity/mortality in newborns. The limited studies examining the pulmonary adaptations in FASD demonstrate decreased surfactant protein A and alveolar macrophage phagocytosis, impaired differentiation, and increased risk of Group B streptococcal pneumonia with no study examining sexual dimorphism in adaptations. We hypothesized that developmental alcohol exposure in pregnancy will lead to sexually dimorphic fetal lung morphological and immune adaptations.

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Due to the complex physical properties of low-permeability glutenite reservoirs, the oil recovery rate with conventional development is low. Surfactants are effective additives for enhanced oil recovery (EOR) due to their good ability of wettability alteration and interfacial tension (IFT) reduction, but the reason why imbibition efficiencies vary with different types of surfactants and the mechanism of enhanced imbibition in the glutenite reservoirs is not clear. In this study, the imbibition efficiency and recovery of surfactants including the nonionic, anionic, and cationic surfactants as well as nanofluids were evaluated and compared with produced water (PW) using low-permeability glutenite core samples from the Lower Urho Formation in the Mahu oil field.

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