AI Article Synopsis
- The McMurry coupling method allows for selective cross-coupling of diaryl or aryl ketones with different substituted ketones, achieving yields between 53% and 94%.
- The presence of substituents on the ketones is thought to enhance selectivity by interacting strongly with the low-valent titanium used in the reaction.
- After the reaction, these substituents can be removed, enabling effective cross-coupling of structurally similar ketones.
Article Abstract
The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53-94% isolated yields. It is believed that the strong affinity of the substituents to the low-valent titanium surface plays an important role in regards to moderating selectivity. Through the introduction of such substituents followed by their removal post McMurry coupling, structurally similar ketones can be effectively cross-coupled.
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| http://dx.doi.org/10.1021/jo061644d | DOI Listing |
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