Aim: To evaluate the pharmaceutical safety of a Chinese herbal formula, chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study.

Methods: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis.

Results: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug.

Conclusion: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087597PMC
http://dx.doi.org/10.3748/wjg.v12.i46.7497DOI Listing

Publication Analysis

Top Keywords

toxicological study
8
herbal formula
8
formula chunggan
8
chunggan extract
8
acute subacute
8
subacute toxicological
8
female dogs
8
haematology urinalysis
8
study hepatotherapeutic
4
hepatotherapeutic herbal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!