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Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population-based studies.
Diabetes Obes Metab
January 2025
Department of Vascular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.
The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia.
Exp Gerontol
January 2025
Department of Clinical Sciences and Community Health, University of Milan, Via della Commenda 19, 20122 Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. Electronic address:
Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called "inflammaging". Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty.
View Article and Find Full Text PDFAssociation of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults.
Neurology
February 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background And Objectives: Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and dementia in community-dwelling older adults.
View Article and Find Full Text PDFThe Impact of Physical Therapy Postprofessional Education Programs on Productivity in a Large Academic Medical Center.
J Phys Ther Educ
January 2025
John J. DeWitt is the associate director, education and professional development and associate clinical professor in the Rehab Services at The Ohio State University Wexner Medical Center, and School of Health & Rehabilitation Sciences, College of Medicine, The Ohio State University, 453 W 10th Ave, Rm 516, Columbus, OH 43210 Please address all correspondence to John J. DeWitt.
Introduction: Emerging evidence shows positive impact of postprofessional physical therapy education (residency and fellowship) specific to participants; however, outcomes on organizational impact are largely unknown. The purpose of this project was to describe the impact residency and fellowship training has on financial metrics. A secondary purpose of this case study was to describe trends associated with higher productivity.
View Article and Find Full Text PDFImpact of frailty and comorbidity on initial response to lung cancer screening invitation and low-dose CT screening uptake: Findings from the Yorkshire Lung Screening Trial.
J Med Screen
January 2025
Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK.
Background: Low-dose computed tomography screening reduces lung cancer-specific mortality in high-risk individuals. Lung cancer risk factors overlap with comorbid diseases, highlighting the significance of frailty and comorbidities for lung cancer screening (LCS). Here, we describe the prevalence of frailty and comorbidity in those invited for LCS and evaluate their associations with response to telephone risk assessment invitation and subsequent uptake of LCS.
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