Perimenopause represents a significant transition in a woman's life. The evidence to support an association between perimenopause and depression is mixed, yet recent prospective studies have provided stronger evidence to support such an association. Interpretation of study data are complicated by methodological issues, such as a lack of standard definition for perimenopause or depression, reducing comparability. A variety of causal factors, including psychological, genetic and physiological, have been implicated in depression during perimenopause, which lends weight to a multifactorial model. Physicians should consider initiating dialogue about menopause and symptom relief at age 40 and screening perimenopausal women for depressive symptoms. Selective serotonin reuptake inhibitors are a first line of treatment for depression, but hormone therapy could be considered for women experiencing menopausal symptoms unless there are contraindications. Future research should focus on establishing temporality and studying these potential relationships among women of different ethnicities.
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| http://dx.doi.org/10.1016/j.bpobgyn.2006.11.002 | DOI Listing |
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Article Synopsis
- This study aimed to understand the varying symptoms of perimenopause by using advanced statistical methods to create a comprehensive assessment framework that combines multiple scales related to insomnia, anxiety, and depression.
- A clinical study in Guangzhou enrolled 336 perimenopausal patients, and a framework was developed to identify six factors affecting their experience, such as sleep disturbance and fatigue, validated through psychometric analysis.
- The findings suggested four distinct profiles of perimenopause symptoms, highlighting the complex and varied nature of the condition across different individuals.
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