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Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase. | LitMetric

[Structure: see text] The pKa's of the 6-CH groups of N-methyl-2-pyridone and N-methyl-4-pyridone in aqueous solution were determined. No correlation between the stability of the carbanions and the rate of decarboxylation of the corresponding carboxylic acids was found.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743169PMC
http://dx.doi.org/10.1021/ol0624981DOI Listing

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