Objective: Determine the content of ursolic acid of Liuwei Dihuangwan.
Method: Using NIR with PLS, PCA-BPANN and WT-BPANN.
Result: The predication recovery were 100.7%, 100.6%, 100.1%, and the RSD were 5.42%, 6.49%, 6.52% respectively.
Conclusion: NIR can be used in the determination of ursolic acid, which set up the foundation of on-line control of traditional Chinese medicine.
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Nan Fang Yi Ke Da Xue Xue Bao
January 2025
Department of Infection, Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
Objectives: To investigate the active ingredients in Hedyotis diffusa-Scutellaria barbata D. Don and the main biological processes and signaling pathways mediating their inhibitory effect on primary hepatocellular carcinoma (HCC).
Methods: The core intersecting genes of HCC and the two drugs were screened from TCMSP, Uniport, Genecards, and String databases using Cytoscape software, and GO and KEGG enrichment analyses of the intersecting genes were conducted.
Nat Prod Res
January 2025
The College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
An endophytic actinomycetes, , was -isolated from the leaves of Hook. et Arn. Five compounds were separated from the ethyl acetate extract of the fermentation broth of endophytic actinomycetes, and their structures were confirmed by utilising methods such as nuclear magnetic resonance, mass spectrometry, and literature references.
View Article and Find Full Text PDFMolecules
December 2024
Ufa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Science, 71, Prospect Octyabrya, Ufa 450054, Russia.
Alzheimer's disease (AD) poses a significant public health issue. Despite the fact that today there are several methods of maintenance therapy, one of the most widely used methods is designed to correct the deficiency of acetylcholine. In the search for new potential inhibitors of cholinesterase enzymes, eight new derivatives of 3-oxo- or 2,3-indolo-triterpenic acid conjugated with amino-quinuclidine bicyclic cores were designed and synthesized.
View Article and Find Full Text PDFToxicon
January 2025
College of Biological Sciences and Technology, YiLi Normal University, China. Electronic address:
Background: Radiotherapy is essential for the management of esophageal squamous cell carcinoma (ESCC). However, ESCC cells are highly susceptible to developing resistance to radiotherapy, leading to poor prognosis. Ursolic acid (UA) is a herbal monomer, has multiple medicinal benefits like anti-tumor.
View Article and Find Full Text PDFComb Chem High Throughput Screen
January 2025
KIPS, Shri Shankaracharya Professional University, Bhilai, Chhattisgarh, India.
The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine.
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