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Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice. | LitMetric

AI Article Synopsis

  • The gastrointestinal tract is a key entry point for prion diseases, which occur when the normal prion protein (PrP(c)) changes into a harmful form (PrP(Sc)).
  • The study aimed to investigate where PrP(c) is located in the small intestine of cattle (bovine) and mice (murine), revealing differences in its distribution between the two species.
  • In cattle, PrP(c) was mostly found in the duodenum and in serotonin-producing cells, while in mice, it was present in various epithelial cells and follicular dendritic cells in Peyer's patches.

Article Abstract

The gastrointestinal tract is thought to be the main site of entry for the pathological isoform of the prion protein (PrP(Sc)). Prion diseases are believed to result from a conformational change of the cellular prion protein (PrP(c)) to PrP(Sc). Therefore, PrP(c) expression is a prerequisite for the infection and spread of the disease to the central nervous system. However, the distribution of PrP(c) in the gut is still a matter of controversy. We therefore investigated the localization of PrP(c) in the bovine and murine small intestine. In cattle, most PrP(c) positive epithelial cells were detected in the duodenum, while a few positive cells were found in the jejunum. PrP(c) was expressed in serotonin producing cells. In bovine Peyer's patches, PrP(c) was distributed in extrafollicular areas, but not in the germinal centre of the jejunum and ileum. PrP(c) was expressed in myeloid lineage cells such as myeloid dendritic cells and macrophages. In mice, PrP(c) was expressed in some epithelial cells throughout the small intestine as well as in cells such as follicular dendritic cell in the germinal centre of Peyer's patches. In this study, we demonstrate that there are a number of differences in the localization of PrP(c) between the murine and bovine small intestines.

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Source
http://dx.doi.org/10.1007/s00418-006-0250-xDOI Listing

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