AI Article Synopsis
- The study investigated the changes in hippocampal volume in children with childhood onset schizophrenia (COS) using serial brain MRI scans over time.
- Results revealed a significant overall reduction (9-10%) in total hippocampal volume in COS subjects that remained stable from ages 9 to 26.
- However, sub-regional analysis indicated that while the anterior and posterior parts of the hippocampus experienced volume loss, the body of the hippocampus actually gained volume, highlighting varied impacts on different hippocampal regions in schizophrenia.
Article Abstract
Prior cross-sectional anatomic brain imaging studies of the hippocampus in schizophrenia have generally shown loss in total hippocampal volume although the progressive course of these changes remains unknown. We report the first prospective sub-regional maps of hippocampal development in childhood onset schizophrenia (COS), reconstructed from serial brain MRI scans of 29 children with COS scanned every 2 years (87 scans) and compared to 31 controls matched for age, sex, and scan interval (94 scans). As expected, the COS subjects showed significant bilateral deficits (9-10%) in total hippocampal volume which remained consistent between age 9 and 26. However sub-regional maps showed heterogeneous changes with loss of hippocampal volume in both anterior as well as posterior ends while the body of the hippocampus gained in volume suggesting that hippocampal subunits are differentially affected in schizophrenia.
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| http://dx.doi.org/10.1016/j.schres.2006.10.014 | DOI Listing |
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