Calcium oxalate monohydrate (COM), which represents a major component of kidney stones, is an end metabolite of ethylene glycol. COM accumulation has been linked with acute renal toxicity in ethylene glycol poisoning. COM injures the kidney either by directly producing cytotoxicity to the kidney cells or by aggregating in the kidney lumen leading to the blockage of urine flow. The present studies were designed to examine whether aluminum citrate could reduce the toxicity of COM. Toxicity was determined in human proximal tubule cells by leakage of lactate dehydrogenase or uptake of ethidium homodimer and in erythrocytes by degree of hemolysis. Aluminum citrate significantly inhibited the leakage of lactate dehydrogenase from human proximal tubule cells and protected against cell death from COM. The inhibitory effect of aluminum citrate was greater than that of other citrate or aluminum salts such as sodium citrate, aluminum chloride, calcium citrate, ammonium citrate or potassium citrate. Aluminum citrate significantly inhibited the aggregation of COM crystals in vitro and decreased red cell membrane damage from COM. Aluminum citrate appeared to directly interact with COM, but not with the cell membrane. As such, aluminum citrate reduced the cytotoxicity by a physico-chemical interaction with the COM surface, and not by dissolving the COM crystals. These studies suggest that aluminum citrate may protect against tissue damage that occurs with high levels of oxalate accumulation, especially in ethylene glycol poisoning and possibly in hyperoxaluric states.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tox.2006.11.046 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High Performance of Commercial PAC on the Simultaneous Desulfurization and Denitrification of Wastewater From a Coal-Fired Heating Plant.
Front Chem
July 2022
School of Construction and Environmental Engineering, Shenzhen Polytechnic, Shenzhen, China.
The flue gas desulfurization wastewater is highly saline and has too many refractory pollutants to be recycled during the desulfurization process of the coal-fired heating plant. Given that waste heat is abundant in coal-fired heating plants, a thermal treatment method was developed to simultaneously remove sulfates and nitrates from the wastewater, with the production of chemical-grade natroalunite and recycled water. The results showed that sulfates and nitrates were 50.
View Article and Find Full Text PDFPhysiology-based toxicokinetic modelling of aluminium in rat and man.
Arch Toxicol
September 2021
Institute of Mathematics, Mathematical Modelling and Systems Biology, University of Potsdam, Potsdam, Germany.
A sufficient quantitative understanding of aluminium (Al) toxicokinetics (TK) in man is still lacking, although highly desirable for risk assessment of Al exposure. Baseline exposure and the risk of contamination severely limit the feasibility of TK studies administering the naturally occurring isotope Al, both in animals and man. These limitations are absent in studies with Al as a tracer, but tissue data are limited to animal studies.
View Article and Find Full Text PDFCalcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation.
Cardiovasc Toxicol
December 2020
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, 71130-3932, USA.
One characteristic of ethylene glycol overdose is a cardiopulmonary syndrome including hypertension and pulmonary edema with pathology indicating damage to the endothelium of heart, lung and brain vessels. The mechanism of the cardiopulmonary toxicity is unknown, but has been linked with accumulation of the metabolite calcium oxalate monohydrate (COM) in the endothelium. These studies have evaluated the hypothesis that COM or the oxalate ion produces endothelial damage in vitro and that damage is linked with induction of reactive oxygen species (ROS).
View Article and Find Full Text PDFChemical Speciation of Aluminum in Wine by LC-ICP-MS.
Molecules
February 2020
Department of Analytical and Environmental Chemistry, Adam Mickiewicz University Poznań, Faculty of Chemistry, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Aluminum is very common in the natural environment and in everyday human life. We are living in the "aluminum age." Its average daily intake should not exceed a few mg/day.
View Article and Find Full Text PDFNovel sodium silicate/polymer composite gels for the prevention of spontaneous combustion of coal.
J Hazard Mater
June 2019
College of Mining and Safety Engineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China; State Key Laboratory of Mining Disaster Prevention and Control Co-found by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao, Shandong 266590, China.
Novel gel materials are proposed for fire prevention and extinction in coal mines, where spontaneous combustion of coal continues to pose a significant risk. Cationic polyacrylamide (CPAM), anionic polyacrylamide (HPAM), and carboxymethyl cellulose (CMC) were each introduced separately into a sodium silicate (WG) gel, to obtain three gels labeled as CPAM/WG, HPAM/WG, and CMC/WG. A crosslinking agent, aluminum citrate, was subsequently added to the HPAM/WG and CMC/WG gels to afford two novel interpenetrating network hydrogels, HPAM-Al/WG and CMC-Al/WG, respectively.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!