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Radiosynoviorthesis with [90Y] Yttrium citrate in refractory synovitis of the knee: Experience of 2 reference hospitals.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
November 2024
Unidad de Medicina Nuclear, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Introduction: To describe the therapeutic efficacy of radiosynoviorthesis with [Y]Yttrium citrate (Y), in patients with chronic knee synovitis refractory to systemic treatments and/or infiltrations, correlating the results with the different etiologies and degenerative changes that they showed, in order to optimize the indication of the technique.
Material And Methods: Observational retrospective study with 32 patients (22 men and 10 women) and 34 knees, with refractory chronic knee synovitis, who underwent radiosynoviorthesis between January 2013 and December 2022. Its efficacy was described and analyzed by the subjective improvement referred by the patients and its relationship with the existing etiologies and radiological degenerative changes, expressed by the Kellgren-Lawrence (K-L) scale.
Current radioisotopes and radiopharmaceuticals for radiosynoviorthesis: basic and applied characteristics, production and availability.
Q J Nucl Med Mol Imaging
December 2022
Homi Bhabha National Institute, Mumbai, India -
This overview describes the basic characteristics and chemistry, production and the clinical applications and use of radiopharmaceuticals pertaining to radiosynoviorthesis (RSO). In each of the case scenarios, the physical and clinical parameters that serve as determinants and govern the choice of a particular radionuclide employed for RSO are discussed. References have been drawn on the fundamentals of RSO where applicable, including a brief review of the principles and mechanism of action, the indication and efficacy of RSO in different disease conditions and suggestions set out by the current guideline recommendations.
View Article and Find Full Text PDFIntra-articular Treatment of Digital Osteoarthritis by Radiosynoviorthesis-Clinical Outcome in Long-term Follow-up.
Clin Nucl Med
November 2022
Abteilung für Nuklearmedizin, Privatklinik Villach, Austria.
Purpose: This retrospective study analyzed the long-term effects of radiosynoviorthesis (RSO) with special emphasis to local joint pain in patients from 4 different RSO centers in Germany and Austria.
Methods: A total of 168 finger joints in 147 patients with digital joint OA were investigated. The indication for RSO was based on both clinical complaints and a proven synovitis, despite anti-inflammatory pharmacotherapy and previous intra-articular corticosteroid injections.
The future of radiosynoviorthesis: bright or bleak?
Q J Nucl Med Mol Imaging
December 2022
Department of Nuclear Medicine University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Radiosynoviorthesis (RSO) is a decades known, effective intra-articular nuclear medicine local therapy, with few rare side-effects, in which inflamed synovial membrane is treated by means of colloidal beta-emitters. There are major variations worldwide in terms of acceptance, frequency of use and approved indications for this procedure. Thus, reliable figures that reflect reality are only available for a few countries.
View Article and Find Full Text PDFRadiosynoviorthesis: almost seventy years of experience but still somewhat fameless.
Q J Nucl Med Mol Imaging
December 2022
Department of Nuclear Medicine, Northwest Clinics, Alkmaar, the Netherlands.
Article Synopsis
- Radiosynoviorthesis (RSO) is a radiation treatment for chronic joint inflammation (synovitis) that's been around for over 50 years, but it's still underused in many areas across the globe.
- The process involves injecting radioactive particles into the affected joint, which are then absorbed by inflammatory cells, leading to localized damage of the synovial tissue and reduced inflammation.
- While research shows RSO is generally effective for persistent synovitis due to various conditions, its success may decline over time, and evidence for its use in specific cases like hemophilia and pigmented villonodular synovitis (PVNS) is quite limited.
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