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Phase 2 Trial of Difelikefalin in Notalgia Paresthetica.
N Engl J Med
February 2023
From the Kimberly and Eric J. Waldman Department of Dermatology (B.S.K., M.L.), the Mark Lebwohl Center for Neuroinflammation and Sensation (B.S.K.), the Marc and Jennifer Lipschultz Precision Immunology Institute (B.S.K.), and the Friedman Brain Institute (B.S.K.), Icahn School of Medicine at Mount Sinai, New York; Innovaderm Research, Montreal (R.B.); and Cara Therapeutics, Stamford, CT (K.N., C.M., N.S., A.J., J.C., J.G.).
Article Synopsis
- Notalgia paresthetica is a condition causing severe itching in the upper back, and the medication difelikefalin is being tested for its effectiveness in treating this issue.
- In a phase 2 clinical trial, 126 patients were randomly assigned to receive either difelikefalin or a placebo for 8 weeks, measuring changes in itch intensity using the Worst Itch Numeric Rating Scale (WI-NRS).
- Results showed that the difelikefalin group had a significant reduction in itch scores compared to the placebo group, but also experienced more side effects, suggesting further research is needed for confirmation and safety evaluation.
Fundus Changes in High Myopia in Relation to Axial Length of the Globe.
J Pharm Bioallied Sci
July 2022
Department of Ophthalmology, Indiana Hospital, Mangalore, Karnataka, India.
Purpose: The aim of the study is to correlate between axial length of the eyeball and fundus changes and to know its importance.
Materials And Methods: It was an observational study conducted for a duration of 1 year in patients with myopia more than 1 D and axial length more than 24 mm. A total of 100 eyes were included in the study and all underwent thorough fundus examination.
Onychomycosis in older adults: The age and associated factors affecting the complete cure rate.
Australas J Dermatol
February 2022
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Limited studies exist on the factors associated with a complete cure of onychomycosis in older adults.
Objectives: To determine the age and factors associated with a complete cure among older adults diagnosed with toenail onychomycosis.
Methods: A retrospective cohort study was conducted of 95 older adult patients (aged ≥ 60 years) diagnosed with toenail onychomycosis between January 2016 and December 2017.
JUBLIA (Efinaconazole 10% Solution) in the Treatment of Pediatric Onychomycosis.
Skinmed
December 2021
Ortho Dermatologics, Bridgewater, NJ.
Onychomycosis is a chronic fungal infection of the nails and is commonly observed in adults, especially the elderly, those who are diabetic, have poor peripheral circulation, and are immunocompromised; however, onychomycosis in children is being reported more frequently, especially in older children. There could also be a genetic predisposition to developing onychomycosis. Given that onychomycosis is uncommon in children, it is important to confirm the diagnosis mycologically.
View Article and Find Full Text PDFPathologic myopia: an overview of the current understanding and interventions.
Glob Health Med
June 2020
Department of Ophthalmology, National Center for Global Health and Medicine, Tokyo, Japan.
Pathologic myopia is a major cause of low vision and blindness worldwide. Its social and economic burden has been demonstrated by epidemiological studies. There have been recent advances in the classification system for myopic maculopathy that enables clinicians to describe different types of lesions, including tessellated fundus, diffuse/patchy chorioretinal atrophy, macular atrophy, lacquer cracks, choroidal neovascularization (CNV), and Fuchs' spot, in a standardized format.
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