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Construction of a prognostic prediction model for colorectal cancer based on 5-year clinical follow-up data.
Sci Rep
January 2025
School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Colorectal cancer (CRC) is a prevalent malignant tumor that presents significant challenges to both public health and healthcare systems. The aim of this study was to develop a machine learning model based on five years of clinical follow-up data from CRC patients to accurately identify individuals at risk of poor prognosis. This study included 411 CRC patients who underwent surgery at Yixing Hospital and completed the follow-up process.
View Article and Find Full Text PDFCharacteristics and prognosis of patients with pancreatic adenocarcinoma not expressing CA19-9: Analysis of the National Cancer Database.
Pancreatology
December 2024
Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA; University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:
Article Synopsis
- Around 5-10% of pancreatic cancer patients don't express CA 19-9, and it's unclear how this affects their cancer severity and prognosis.
- A study analyzed data from 88,749 pancreatic cancer patients, finding that non-expressors had a higher chance of distant metastasis and a shorter median overall survival compared to those with normal CA 19-9 levels.
- The findings suggest that patients who are non-expressors of CA 19-9 might need different diagnostic approaches and more aggressive treatment strategies.
Prognosis prediction of PDAC via detection of O-glycan altered extracellular vesicles in perioperative sera.
Cancer Sci
November 2024
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that is hard to diagnose and has a poor outlook, highlighting the need for better biomarkers for diagnosis and prognosis.
- A study identified extracellular vesicles (EVs) marked by O-glycan-binding lectins (ACA) as a promising diagnostic tool for PDAC, using a system called ExoCounter.
- Analysis of serum samples from 44 patients showed that an increase in ACA-positive EVs post-surgery was linked to shorter overall survival and recurrence-free survival, making it a potential independent predictor of poor prognosis in PDAC.
The effect of combined head and tail approach during laparoscopic D3 lymph node dissection on pain severity and complications in patients with right colon cancer.
Clin Transl Oncol
January 2025
Department of Gastrointestinal Surgery, First Affiliated Hospital of Wannan Medical College, No. 2, Zheshan West Road, Jinghu District, Wuhu, 241000, Anhui, China.
Objective: To examine the impact of a combined craniocaudal approach on pain and complications during laparoscopic D3 lymph node dissection in clients diagnosed with right colon cancer (RCC).
Methods: 100 RCC patients were divided into Group A and Group B. Both groups underwent laparoscopic D3 lymph node dissection, with Group A undergoing an intermediate approach and Group B undergoing a combined head and tail approach.
Radiologic Occult Metastases in Pancreatic Cancer: Analysis of Risk Factors and Survival Outcomes in the Age of Contemporary Neoadjuvant Multi-agent Chemotherapy.
Ann Surg Oncol
September 2024
Department of Surgery, Division of Surgical Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
Background: Radiologic occult metastatic disease (ROMD) in patients with pancreatic ductal adenocarcinoma (PDAC) who undergo contemporary neoadjuvant chemotherapy (NAC) has not been well studied. This study sought to analyze the incidence, risk factors, and oncologic outcomes for patients who underwent the NAC approach for PDAC.
Methods: A retrospective review analyzed a prospectively maintained database of patients who had potentially resectable PDAC treated with NAC and were offered pancreatectomy at our institution from 2011 to 2022.
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