The objective of this retrospective study was to evaluate the role of MICA in heart graft acceptance. Pre- and post-transplant sera from 31 patients were evaluated for MICA antibodies by cytotoxicity on recombinant cell lines and soluble MICA (sMICA) concentrations by ELISA. The results demonstrated that the patients with post-transplant anti-MICA antibodies were at a high risk for the development of severe acute rejection (AR) (p<0.03; OR=8.5). However, the presence of post-transplant sMICA was found to be associated with functioning grafts without AR episodes (p<0.03, OR=7.9). In this preliminary survey, the negative association of sMICA with AR was found to be in the absence of MICA antibodies. Further research is needed to clarify the role of sMICA in allograft acceptance. Post-transplant evaluation of humoral immune response to MICA and the measure of sMICA in patient's sera may provide a good predictor of AR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.trim.2006.09.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Soil stressors on ecophysiology of bauxite mine impacted soil: Heavy metal-acidity-organic matter nexus.
J Environ Qual
January 2025
Agricultural and Ecological Research Unit, Indian Statistical Institute, Giridih, Jharkhand, India.
Article Synopsis
- This study explores how bauxite mining impacts soil quality and microbial health in mining-adjacent areas, which has been under-researched compared to other types of mining like coal and copper.
- Soil samples from locations near an active bauxite mine showed high levels of heavy metals (like chromium and lead), acidity, and aluminum, negatively affecting important microbial indicators such as enzyme activity and microbial biomass.
- The research found that the concentrations of organic carbon could help mitigate some of the acidity effects, with acid phosphatase enzyme being a key factor in differences seen across various sampling sites.
Novel and potent MICA/B antibody is therapeutically effective in mutant lung cancer models.
J Immunother Cancer
January 2025
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Background: Concurrent (STK11, KL) mutant non-small cell lung cancers (NSCLC) do not respond well to current immune checkpoint blockade therapies, however targeting major histocompatibility complex class I-related chain A or B (MICA/B), could pose an alternative therapeutic strategy through activation of natural killer (NK) cells.
Methods: Expression of NK cell activating ligands in NSCLC cell line and patient data were analyzed. Cell surface expression of MICA/B in NSCLC cell lines was determined through flow cytometry while ligand shedding in both patient blood and cell lines was determined through ELISA.
Corrosion Characteristics of Typical Gangue Minerals in Biometallurgical Systems.
Appl Biochem Biotechnol
December 2024
School of Metallurgy, Northeastern University, Shenyang, China.
Electrochemical and shake flask tests were used to examine the corrosion characteristics of typical gangue minerals in biometallurgical systems and their impact on microbial communities. The results show that the solubility order of the three gangue minerals is feldspar, mica, and quartz in descending order. Their corrosion processes are mainly controlled by cathodic electron-donating processes.
View Article and Find Full Text PDFAggregation Characteristics of Biobased Anionic Surfactant, Hydroxy Alkane Sulfonate in Aqueous CaCl Solutions: Vesicle and Supported Bilayer Formation.
Langmuir
October 2024
R&D, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan.
Vesicles are known to spontaneously adsorb onto solid-liquid interfaces and to form supported bilayers in aqueous solution. Cationic surfactants have typically been used to generate supported bilayers because solid surfaces in water are often negatively charged. The present study investigated the aggregation behavior of an anionic surfactant, hydroxy alkane sulfonate having a C18 alkyl chain (C18HAS) in aqueous CaCl solutions.
View Article and Find Full Text PDFAssembly of Hydrophobin class I from Agaricus bisporus produced different amyloid-like fibrils.
Biochim Biophys Acta Proteins Proteom
January 2025
Universidad Autónoma Metropolitana-Cuajimalpa. Departamento de Ciencias Naturales. Laboratorio de Biofisicoquímica, Av. Vasco de Quiroga 4871. Col. Santa Fe Cuajimalpa, Alcaldía Cuajimalpa, Mexico City, CP 05348, Mexico. Electronic address:
This work studied the extraction, purification, characterization, and assembly of hydrophobin class I from Agaricus bisporus (ABH4). The highest soluble protein concentration was obtained from the pinhead, the extraction and purification were efficient for hydrophobin class I, obtaining a band of 12 kDa. The identified sequence of hydrophobin presented the eight cysteine residues; for the prediction of the structure, hydrophobin presented more alpha helix structures than beta sheets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!