The local statistical and geometric structure of three-dimensional turbulent flow can be described by the properties of the velocity gradient tensor. A stochastic model is developed for the Lagrangian time evolution of this tensor, in which the exact nonlinear self-stretching term accounts for the development of well-known non-Gaussian statistics and geometric alignment trends. The nonlocal pressure and viscous effects are accounted for by a closure that models the material deformation history of fluid elements. The resulting stochastic system reproduces many statistical and geometric trends observed in numerical and experimental 3D turbulent flows, including anomalous relative scaling.
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http://dx.doi.org/10.1103/PhysRevLett.97.174501 | DOI Listing |
J Clin Pharmacol
January 2025
Department of Pharmacy, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Albuvirtide (ABT) is a novel long-acting fusion inhibitor for human immunodeficiency virus type 1 (HIV-1), and may be co-administered with rifampicin (RIF) in patients concurrent with tubercle bacillus and HIV-1. This study was conducted to investigate the pharmacokinetic effect of co-administration of the two drugs. In the study, 24 healthy volunteers were randomized to receive ABT alone or with RIF.
View Article and Find Full Text PDFFront Cell Dev Biol
January 2025
Department of Physics, Faculty of Sciences, FAU Erlangen-Nuremberg, Erlangen, Germany.
The glycocalyx is a dense and dynamic layer of glycosylated species that covers every cell in the human body. It plays crucial roles in various cellular processes in health and disease, such as cancer immune evasion, cancer immune therapy, blastocyst implantation, and functional attenuation of membrane protein diffusion. In addition, alterations in glycocalyx structure may play an important role in ocular surface diseases, e.
View Article and Find Full Text PDFProteins
January 2025
Department of Statistics, Florida State University, Tallahassee, Florida, USA.
The structures of metalloproteins are essential for comprehending their functions and interactions. The breakthrough of AlphaFold has made it possible to predict protein structures with experimental accuracy. However, the type of metal ion that a metalloprotein binds and the binding structure are still not readily available, even with the predicted protein structure.
View Article and Find Full Text PDFSci Total Environ
January 2025
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Road, Shanghai 200092, China. Electronic address:
Background: Cd has no known biological function and poses significant health risks in humans. Children are particularly susceptible to Cd toxicity due to their higher absorption rates and weaker biological defenses. However, national blood Cd levels (BCLs) in Chinese children aged 0-6 years remain unclear.
View Article and Find Full Text PDFDentomaxillofac Radiol
January 2025
Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Objectives: This meta-research assessed methodologies used for evaluating peri-implant marginal bone levels on digital periapical radiographs in randomised clinical trials published between 2019 and 2023.
Methods: Articles were searched in four databases. Data on methods for assessing peri-implant marginal bone levels were extracted.
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