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[Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic agents]. | LitMetric
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[Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic agents].

M E Neverova N A Mkrtumova O V Fidelina E I Adamskaia I B Tsorin G G Chichkanov L I Chudakov

Eksp Klin Farmakol

Published: January 2007

Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verapamil.

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