AI Article Synopsis
- 5-azacytidine significantly increases the levels of tyrosine aminotransferase in the liver of suckling rats, but this effect is eliminated when the adrenal glands are removed.
- The treatment leads to a decrease in cytosolic glucocorticoid receptors and an increase in their presence in the nuclei of cells.
- Unlike dexamethasone's effects, the antiglucocorticoid RU 486 does not prevent the induction of tyrosine aminotransferase or the movement of glucocorticoid receptors into the nuclei when 5-azacytidine is used.
Article Abstract
The nucleoside analog 5-azacytidine is able to induce tyrosine aminotransferase several-fold in the liver of suckling rats. Bilateral adrenalectomy abolishes this inducing effect. The drug also decreases significantly the concentration of cytosolic glucocorticoid receptor accompanied by an increase of the glucocorticoid receptor concentration in the nuclei. The antiglucocorticoid RU 486 which abolishes the induction of tyrosine aminotransferase and serine dehydratase by dexamethasone very effectively is not able to inhibit either the induction of tyrosine aminotransferase or the translocation of the glucocorticoid receptor into the nuclei by 5-azacytidine.
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| http://dx.doi.org/10.1016/0065-2571(91)90016-f | DOI Listing |
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