A derivative of pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT), which may form various keto-enol tautomers suitable for forming base pairs with all natural bases, and is thus expected to serve as a universal base, was synthesized. The ability of PPT to form base pairs with natural bases was evaluated by UV analysis.
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http://dx.doi.org/10.1093/nass/49.1.119 | DOI Listing |
Otol Neurotol Open
December 2024
Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL.
The University of Miami Ear Institute (UMEI) was conceived and founded by Dr. W. Jarrard (Jerry) Goodwin in 1990, then Chairman of the University of Miami Department of Otolaryngology-Head and Neck Surgery.
View Article and Find Full Text PDFCurr Opin Biotechnol
December 2024
Department of Life Sciences, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:
The genetic code is a universally conserved mechanism that translates genetic information into proteins, consisting of 64 codons formed by four nucleotide bases. With a few exceptions, the genetic code universally encodes 20 canonical amino acids (AAs) and three stop signals, with many AAs represented by multiple codons. Genetic engineering has expanded this system through approaches like codon reassignment and synthetic base pair introduction, allowing for the incorporation of noncanonical AAs (ncAAs) into proteins, known as genetic code expansion (GCE).
View Article and Find Full Text PDFBMC Psychol
December 2024
NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.
Background: Sleep is substantial issue for hospital inpatients and can negatively affect healing and recovery. There is a good evidence-base for interventions which can improve sleep, however currently they are not being implemented into NHS practice. To address the evidence-practice gap, we have conducted early-phase development for an inpatient sleep intervention (ASLEEP); a multi-level intervention to improve inpatient sleep in UK hospital wards.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
Department of Operative Dentistry, Aichi Gakuin School of Dentistry, Nagoya 464-8651, Japan.
Universal shade flowable composites have been introduced to mimic tooth structure with reduced color mismatch and reduced chair time and cost. However, the polymerization shrinkage of resin material may lead to sensitivity and restoration failure. The purpose of this study was to compare the polymerization shrinkage of recently introduced universal shade flowable resin-based composites using both wet and dry density methods.
View Article and Find Full Text PDFArthritis Care Res (Hoboken)
December 2024
University of Calgary, Calgary, Alberta, Canada.
Objective: Estimate the budget impact of funding a standardized education and exercise therapy program (GLA:D®) for people with hip and knee OA waiting for total joint replacement (TJR) consultation in a universal publicly insured healthcare system in Canada.
Methods: We built a budget impact analysis (BIA) model to estimate the annual cost of providing GLA:D® program to people waiting for TJR consultation and then forecasted a three-year budget cycle. The base case assumes 40% attend GLA:D®, 11% avoid surgery, uniform care delivery, training costs are incurred separately, and the healthcare system has enough trained staff to meet demand.
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