AI Article Synopsis
- Recent research reveals that nuclear localized small modulatory double-stranded RNA (smRNA) coding NRSE sequences activate transcription of NRSE genes in adult hippocampal neural stem cells.
- These smRNAs, about 20 base pairs long, aid in neuronal differentiation and interact with the NRSF/REST transcription factor, influencing neuron-specific gene expression.
- The study highlights the significant role of non-coding RNAs in regulating cell fate during adult neurogenesis, introducing a novel mechanism involving dsRNA and DNA/protein interactions.
Article Abstract
Recently we found that the nuclear localized small modulatory double-stranded (ds) RNA (smRNA) coding NRSE sequences triggered activation of transcription of NRSE genes in adult hippocampal neural stem cells. NRSE smRNA, which are non-coding dsRNAs about 20 bp in length, reside in the nucleus and play a critical role in mediating neuronal differentiation. These smRNAs carry the sequence of NRSE/RE1, which is recognized by the NRSF/REST transcription factor. The NRSE sequences are embedded widely in the genomic region, typically in promoters of neuron-specific genes. The mechanism of action appears to be mediated through a specific interaction between dsRNA and DNA/protein interaction, rather than through siRNA or miRNA. The discovery of smRNAs extends the important contribution of non-coding RNAs as key regulators of cell fate choice for adult neurogenesis.
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| http://dx.doi.org/10.1093/nass/49.1.87 | DOI Listing |
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The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.
Nucleic Acids Symp Ser (Oxf)
June 2007
Gene Function Research Center, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8562, Japan.
Article Synopsis
- Recent research reveals that nuclear localized small modulatory double-stranded RNA (smRNA) coding NRSE sequences activate transcription of NRSE genes in adult hippocampal neural stem cells.
- These smRNAs, about 20 base pairs long, aid in neuronal differentiation and interact with the NRSF/REST transcription factor, influencing neuron-specific gene expression.
- The study highlights the significant role of non-coding RNAs in regulating cell fate during adult neurogenesis, introducing a novel mechanism involving dsRNA and DNA/protein interactions.
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Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.
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Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
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