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Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA. | LitMetric
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Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.

Kazuhiko Nakatani Shinya Hagihara Yuki Goto Akio Kobori Masaki Hagihara Gosuke Hayashi Motoki Kyo Makoto Nomura Masaki Mishima Chojiro Kojima

Nucleic Acids Symp Ser (Oxf)

Graduate School of Engineering, Kyoto University, Kyoto 618-8510, Japan.

Published: June 2007

NMR structure of the first identified ligand, naphthyridine-azaquinolone (NA), complexed with the CAG-CAG triad is reported. The determined structure revealed the invasive ligands binding to the A-A mismatch and flanking G-C base pairs, causing the widowed cytosines to flip out from pi-stack. Hydrogen-bond pairs between NA and DNA, naphthyridine-guanine and azaquinolone-adenine, are well stacked in the right-handed DNA helix, showing structural mimicry of Watson-Crick base pairing. This is the first observation that the small molecular ligand induced the base flipping of the nucleotide base in the Watson-Crick base pair.

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 Source
http://dx.doi.org/10.1093/nass/49.1.49DOI Listing

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