Metastatic tumors in the choroid plexus are generally considered to be very rare. The authors present a case of lung large cell carcinoma with a single metastatic tumor in the choroid plexus of the lateral ventricle trigone. Precontrast computed tomographic (CT) scans showed an isodensity mass with extensive peritumoral edema, which was considerably enhanced on the postcontrast CT scans. Magnetic resonance (MR) images demonstrated the mass as a low-intensity area on the T1-weighted image and an iso-intensity area on the T2-weighted image. The tumor was clearly differentiated from the peritumoral edema by both CT and MR imaging. The diagnosis was confirmed by surgery.
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http://dx.doi.org/10.2176/nmc.31.152 | DOI Listing |
Background: The choroid plexus (ChP) plays a vital role in CSF production and waste clearance. While existing imaging studies have established connections between ChP volume changes and age-related neurodegenerative diseases, a comprehensive investigation into the microstructural and vascular changes associated with aging remains insufficient. This study aims to explore ChP changes in normal aging using diffusion and perfusion MRI in the HCP-Aging dataset to enhance our understanding of age-related microstructural and vascular changes in the ChP.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Background: The association between [F]Flortaucipir (FTP) and [F]MK6240, two commonly used tau-PET tracers in Alzheimer's disease (AD), varies due to distinct binding properties and off-target signal regions. Our study aims to elucidate the biological factors influencing this association and evaluate the applicability of a common equation across different on-target regions.
Method: 113 individuals from the HEAD dataset (11 young, 58 cognitively unimpaired elderly, and 44 cognitively impaired) underwent [F]MK6240, [F]FTP and Aβ-PET scans.
Background: Tau-PET tracers allow for in vivo Braak staging of individuals in the Alzheimer's disease (AD) continuum. The impact of tracers' characteristics for Braak staging using tau-PET remains unclear. Therefore, we performed a head-to-head comparison of Braak staging using first- and second-generation tau-PET tracers.
View Article and Find Full Text PDFBackground: Mild cognitive impairment (MCI) is currently a clinical diagnosis characterized by decline in memory and daily cognitive function from baseline. Exploratory studies using optical coherence tomography angiography have reported alterations in the retinal capillary plexus vessel density and attenuation of the retinal nerve fiber layer, but these results appear to be mixed. We used ultra-widefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared to controls with normal cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Background: Differences between on- and off-target retention characteristics between [F]MK6240 and [F]Flortaucipir (FTP) complicate the harmonization across tracers. Our objective here was to separate the impact of the reference region by evaluating correlations between [F]MK6240 (MK) and [F]FTP standard uptake values (SUVs).
Method: Participants (Figure 1, n=90) received an amyloid-β (Aβ) PET scan ([C]PIB or [F]NAV4694) and two tau-PET scans: [F]MK (90-110 minutes post-injection) and [F]FTP (80-100 minutes post-injection).
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