Synthesis and properties of DNA analogs consisting of the benzene-phosphate backbone.

Nucleic Acids Symp Ser (Oxf)

Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.

Published: July 2007

This paper describes DNA analog synthesis consisting of the benzene-phosphate backbone, of which the monomer units are built from benzene-core units connected via a biaryl-like axis to the nucleobases. It was found that the duplex comprised of the analogs had a non-helical structure and was thermally more stable than the corresponding natural DNA duplex.

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http://dx.doi.org/10.1093/nass/48.1.17DOI Listing

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