Regressive evolution, the reduction or total loss of non-functional characters, is a fairly common evolutionary phenomenon in subterranean taxa. However, the genetic basis of regressive evolution is not well understood. Here we investigate the molecular evolution of the eye pigment gene cinnabar in several independently evolved lineages of subterranean water beetles using maximum likelihood analyses. We found that in eyeless lineages cinnabar has an increased rate of sequence evolution, as well as mutations leading to frame shifts and stop codons, indicative of pseudogenes. These results are consistent with the hypothesis that regressive evolution of eyes proceeds by random mutations, in the absence of selection, that ultimately lead to the loss of gene function in protein-coding genes specific to the eye pathway.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626372 | PMC |
| http://dx.doi.org/10.1098/rsbl.2005.0358 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knowledge of the natural history of deficiency disorder (CDD) is limited to the results of cross-sectional analysis of largely pediatric cohorts. Assessment of outcomes in adulthood is critical for clinical decision-making and future precision medicine approaches but is challenging because of the diagnostic gap and duration of follow-up that would be required for prospective studies. We aimed to delineate the natural history retrospectively from adulthood.
View Article and Find Full Text PDFGraphical model inference with external network data.
Biometrics
October 2024
Department of Business and Economics, Universitat Pompeu Fabra, Ramon Trias Fargas 25-27, Barcelona 08005, Spain.
A frequent challenge when using graphical models in practice is that the sample size is limited relative to the number of parameters. They also become hard to interpret when the number of variables p gets large. We consider applications where one has external data, in the form of networks between variables, that can improve inference and help interpret the fitted model.
View Article and Find Full Text PDFSuccessful treatment of chronic pulmonary aspergillosis in a patient with early pulmonary tuberculosis and COVID-19: a case report.
Multidiscip Respir Med
December 2024
Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Introduction: Chronic pulmonary aspergillosis (CPA) often develops in residual lesions of pulmonary tuberculosis (PTB). Every year, 112,000 to 160,000 people worldwide will develop post-PTB CPA. The simultaneous occurrence of CPA with the first episode of PTB is rare.
View Article and Find Full Text PDFMental health and justice beyond borders: Global crises, sociopolitical determinants, and contemporary practices in forensic psychiatry.
Int Rev Psychiatry
November 2024
Department of Forensic Psychiatry, University of Bern, Bern, Switzerland.
In an era marked by escalating international crises, environmental shifts, and sociopolitical volatilities, global mental health is facing profound challenges. With its distinctive position at the intersection between clinical and judicial domains, forensic psychiatry can be predisposed to the consequences of adverse external determinants and events. At present, geopolitical conflicts, rising insecurities, climate change, forced and voluntary migration, and regressive sociopolitical ideologies are all compounding role responsibilities, care models, and ethical expectations across forensic-psychiatric practice; in short, complex distal factors are increasingly informing domestic considerations.
View Article and Find Full Text PDFImmuno-oncologic profiling by stage-dependent transcriptome and proteome analyses of spontaneously regressing canine cutaneous histiocytoma.
PeerJ
December 2024
Department of Veterinary Medicine, Freie Universität Berlin, Institute of Veterinary Pathology, Berlin, Germany.
Canine cutaneous histiocytoma (CCH) is a tumor that originates from dermal Langerhans cells and affects particularly young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved, but details remain speculative to date.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!