In a recent article, Rohde & Muller (Rohde & Muller 2005 Nature 434, 208-210) identified a strong 62 Myr cyclicity in the history of marine diversity through the Phanerozoic. The data they presented were highly convincing, yet they were unable to explain what process might have generated this pattern. A significant correlation between observed genus-level diversity (after removal of long-term trends) and the amount of marine sedimentary rock measured at a surface outcrop in Western Europe is demonstrated. This suggests that cyclicity originates from long-term changes in sedimentary depositional and erosional regimes, and raises the strong possibility that the cyclicity apparent in the record of marine fossils is not a biological signal but a sampling signal.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626379 | PMC |
| http://dx.doi.org/10.1098/rsbl.2005.0345 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria.
Discov Oncol
September 2024
Department of Neurosurgery, University Medical Center, Georg-August-University, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
Article Synopsis
- The study compares MRI characteristics of glioblastoma (mGB) and multifocal central nervous system lymphoma (mCNSL) to improve diagnostic accuracy.
- Analysis of MRI findings from 50 patients with each type of cancer revealed distinct differences in lesion morphology, size, and ADC ratios.
- Key findings show that mCNSL typically has solid lesions, smaller sizes, lower ADC ratios, and more susceptibility artifacts, enabling more accurate differentiation from mGB.
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.
Cell
August 2024
Department of Infectious Diseases and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany.
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we identify dexamethasone treatment-induced cellular and molecular changes associated with improved survival in COVID-19 patients. We observed a reversal of transcriptional hallmark signatures in monocytes associated with severe COVID-19 and the induction of a monocyte substate characterized by the expression of glucocorticoid-response genes.
View Article and Find Full Text PDFAssociation of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage.
Crit Care Med
September 2024
Department of Neurosurgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Article Synopsis
- The study aims to understand how fluid balance affects hemoglobin levels and neurologic outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH).
- It analyzes data from the Earlydrain trial involving 237 aSAH patients over an 8-day period in various ICUs, focusing on daily hemoglobin and fluid balance measurements.
- Results indicate that higher fluid balance correlates with greater hemoglobin decline and poorer 6-month outcomes, suggesting fluid overload is a key factor in these complications rather than minor hemoglobin drops.
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!