Anti-epilepsy medications have frequently been used in the treatment of neuropathic pain to reduce the transmission of nociceptive signals.(1,2) Zonisamide is a sulfonamide drug that was approved in 2000 for the adjunctive treatment of partial seizures in adults. Because of the unique combination of mechanisms through which zonisamide functions, it has potential to be a useful option in the treatment of refractory neuropathic pain. We present the case of a patient with refractory neuropathic pain related to idiopathic polyneuropathy, who responded to adjunctive treatment with zonisamide.
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