Avian influenza is an infectious disease that mainly affects birds, caused by influenza A type viruses, in most cases of low pathogenecity. Rapid mutations of these viruses to highly pathogenic forms represent a serious risk for animal and public health. Since 2003, an outbreak of highly pathogenic avian influenza in birds is taking place with transmission and resulting illness in humans and which is believed to be able to start a human influenza pandemic. To face these outbreaks, a joint effort between the animal and public health sector is needed to identify areas affected by animal disease and to intensify surveillance of human cases in them. Control measures in animals must be compatible with risk reduction of human exposure. The aim of this article is to review the general control measures developed against avian influenza in birds, highlighting coordination and communication aspects between Animal Health and Public Health, taking into account that legislation is constantly being updated as the dynamic of the disease changes.
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http://dx.doi.org/10.1590/s1135-57272006000600003 | DOI Listing |
Front Immunol
January 2025
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Introduction: Animal influenza viruses pose a danger to the general public. Eurasian avian-like H1N1 (EA H1N1) viruses have recently infected humans in several different countries and are often found in pigs in China, indicating that they have the potential to cause a pandemic. Therefore, there is an urgent need to develop a potent vaccine against EA H1N1.
View Article and Find Full Text PDFNat Commun
January 2025
Veterinary Epidemiology, Economics and Public Health Group, WOAH Collaborating Centre for Risk Analysis and Modelling, Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, UK.
The World Health Organization describes brucellosis as one of the world's leading zoonotic diseases, with the Middle East a global hotspot. Brucella melitensis is endemic among livestock populations in the region, with zoonotic transmission occurring via consumption of raw milk, amongst other routes. Control is largely via vaccination of small ruminant and cattle populations.
View Article and Find Full Text PDFFront Med
January 2025
Department of Clinical Pharmacology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, 311202, China.
ADC189 is a novel drug of cap-dependent endonuclease inhibitor. In our study, its antiviral efficacy was evaluated in vitro and in vivo, and compared with baloxavir marboxil and oseltamivir. A first-in-human phase I study in healthy volunteers included single ascending dose (SAD) and food effect (FE) parts.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Faculty of Geography, Yunnan Normal University, Kunming, China.
Exposure to infected animals and their contaminated environments may be the primary cause of human infection with the H7N9 avian influenza virus. However, the transmission characteristics and specific role of various influencing factors in the spread of the epidemic are not clearly understood. Therefore, it is of great significance for scientific research and practical application to explore the influencing factors related to the epidemic.
View Article and Find Full Text PDFH5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of hosts in diverse climatic environments. Fortunately, transmission to and between humans is scarce.
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