Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator.

Chem Commun (Camb)

Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.

Published: December 2006

By introducing an intercalator through D-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

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Source
http://dx.doi.org/10.1039/b611078aDOI Listing

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