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Emergence and clinical challenges of ST11-K64 carbapenem-resistant Klebsiella pneumoniae: molecular insights and implications for antimicrobial resistance and virulence in Southwest China.
BMC Infect Dis
January 2025
Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: In clinical practice, the emergence of ST11-K64 carbapenem-resistant Klebsiella pneumoniae (ST11-K64 CRKP) has become increasingly alarming. Despite this trend, limited research has been conducted to elucidate the clinical and molecular characteristics of these strains.
Objectives: This study aimed to comprehensively investigate the clinical characteristics, antimicrobial resistance patterns, resistance and virulence-associated genes, and molecular epidemiology of ST11-K64 CRKP in Southwest China.
High-alcohol-producing Klebsiella pneumoniae aggravates lung injury by affecting neutrophils and the airway epithelium.
Cell Rep Med
December 2024
Capital Institute of Pediatrics, Beijing 100020, China. Electronic address:
We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover that 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory disease severity.
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Department of Clinical Laboratory, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong, China.
Introduction: The exact triggers of gallstone formation remain incompletely understood, but research indicates that microbial infection is a significant factor and can interfere with treatment. There is no consensus on the bile microbial culture profiles in previous studies, and determining the microbial profile could aid in targeted prevention and treatment. The primary aim of this study is to investigate the differences in microbial communities cultured from bile specimens of patients with gallstones.
View Article and Find Full Text PDFGenotypic Characterisation of Carbapenem-Resistant Enterobacteriaceae in a Tertiary Care Hospital in South India.
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Medical Microbiology, Vinayaka Mission's Kirupananda Variyar Medical College and Hospital, Salem, IND.
Introduction The antimicrobial resistance of is variable and is influenced by both geographic location and regional antibiotic use. The overuse of antibiotics, especially in hospitalised patients, suppresses the growth and persistence of drug-resistant bacteria. This study aimed to detect the prevalence of carbapenem-resistant and the genes responsible for the resistance.
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Queensland University of Technology (QUT), Brisbane, QLD, Australia.
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