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Comparison of the analgesic dose of intravenous ketamine versus ketorolac in patients with chest trauma: A randomized double-blind clinical trial.
Acad Emerg Med
December 2024
Fellowship in Emergency Trauma, Montreal General Hospital, McGill University, Montreal, Quebec, Canada.
Background: Pain management is a critical part of treatment in patients with chest trauma. Opioids and nonsteroidal anti-inflammatory drugs have been the most commonly used medications. However, their side effects have drawn attention to other medications.
View Article and Find Full Text PDFRescue Laparoscopy-Assisted Repositioning of a Misdeployed Metal Stent in the Peritoneum Following Endoscopic Ultrasound-Guided Hepaticogastrostomy (with video).
Gastrointest Endosc
November 2024
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Utilization of Enhanced Recovery After Surgery (ERAS) protocol in pediatric laparoscopic sleeve gastrectomy: a quality improvement project.
Pediatr Surg Int
November 2024
Department of Surgery, Nemours Children's Health, 1600 Rockland Road, Wilmington, DE, 19803, USA.
Background: The obesity epidemic has led to an increased number of adolescents requiring metabolic and bariatric surgery (MBS), but there is paucity of data on the impact of implementing all aspects of Enhanced Recovery After Surgery (ERAS) protocols to improve outcomes in this population.
Methods: We implemented a comprehensive ERAS pathway for adolescents undergoing laparoscopic sleeve gastrectomy (LSG). Key elements included pre-operative fasting with carbohydrate loading in the morning of surgery, comprehensive anti-emetic and analgesic regimens including intra-operative lidocaine infusion (initiated before formal ERAS launch), regional anesthesia, and early goal-directed ambulation.
Incidence of post-operative nausea and vomiting after endoscopic bariatric and metabolic therapy procedures and the role of neurokinin-1 receptor antagonists: a retrospective cohort study.
Surg Endosc
December 2024
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 1St Street SW, Rochester, MN, 55905, USA.
Article Synopsis
- The study investigates the incidence of postoperative nausea and vomiting (PONV) in patients who underwent endoscopic bariatric and metabolic therapies (EBMT), focusing on the impact of neurokinin-1 receptor (NK-1) antagonists on PONV rates.
- Out of 404 patients, 62.6% experienced PONV, with significant differences in rates between those who received NK-1 antagonists (35%) and those who did not (74%).
- The findings suggest that using NK-1 antagonists as part of a comprehensive approach to prevent PONV significantly lowers the likelihood of this adverse event in patients recovering from EBMT.
Hypomethylation at PANDAR promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes.
FASEB J
October 2024
Department of Translational Medicine, Federico II University of Naples, Naples, Italy.
Article Synopsis
- * Researchers identified PANDAR, a long non-coding RNA (lncRNA), as significantly up-regulated in APCs of individuals with obesity, particularly those transitioning from normal glucose tolerance to impaired glucose tolerance or T2D.
- * Silencing PANDAR in senescent APCs appears to reverse senescence and enable cell cycle re-entry, suggesting that targeting PANDAR may offer a new approach to prevent or delay the progression toward T2D in obese patients.
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