AI Article Synopsis
- Magnesium can block the N-methyl-D-aspartate receptor's ion channel, potentially helping to prevent central sensitization, which is linked to pain.
- In the study, male Sprague Dawley rats received subcutaneous fentanyl injections to induce hyperalgesia, and magnesium sulfate was administered beforehand to test its preventive effects.
- Results indicated that while fentanyl caused a significant decrease in nociceptive thresholds, magnesium sulfate significantly reduced this pain sensitivity, suggesting it may help manage prolonged pain responses.
Article Abstract
Purpose: Magnesium exerts a physiological block of the ion channel on the N-methyl-D-aspartate receptor, and may therefore prevent the induction of central sensitization. The purpose of this study was to assess whether systemic magnesium can prevent long-lasting hyperalgesia induced by sc fentanyl administration in uninjured rats.
Methods: Long-lasting hyperalgesia was induced in male Sprague Dawley rats with sc fentanyl (four injections, 60 microg x kg(-1) per injection at 15-min intervals). Magnesium sulphate (100 mg x kg(-1)) was injected ip 30 min prior to the first sc fentanyl injection. Sensitivity to nociceptive stimuli (paw-pressure test) was assessed for several days after injections.
Results: Subcutaneous fentanyl led to delayed hyperalgesia associated with a decrease in the nociceptive threshold lasting two days (35% decrease for the maximum effect). Intraperitoneal magnesium sulphate partially but significantly (P < 0.05) prevented the delayed decrease in the nociceptive threshold following sc administration of fentanyl.
Conclusions: This study shows that magnesium may prevent the delayed and prolonged hyperalgesia following fentanyl administration in rats.
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| http://dx.doi.org/10.1007/BF03021578 | DOI Listing |
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