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Full-Endoscopic Anterior Cervical Decompression and Fusion for Cervical Myelopathy.
Neurospine
December 2024
Morgenstern Institute of Spine, Centro Médico Teknon, Barcelona, Spain.
This article aims to introduce a novel full-endoscopic anterior cervical discectomy and fusion (ACDF) procedure to treat cervical myelopathy. Adoption of endoscopic anterior cervical procedures has been lagging due to safety concerns and the necessity of placing an interbody cage. We have developed novel instrumentation and a modified percutaneous anterior cervical approach that allows a safe and reproducible full-endoscopic ACDF.
View Article and Find Full Text PDFStructure characterization and preliminary immune activity of a glucomannan purified from Allii Tuberosi Semen.
Carbohydr Res
January 2025
College of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo, Shaanxi, 726000, PR China. Electronic address:
A novel glucomannan, named ATSW-1, was obtained from Allii Tuberosi Semen by ion and gel permeation chromatography purification. Its structure was characterized using high-performance chromatography, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. The in vitro immune activities of ATSW-1 were examined using the Cell Counting Kit-8, the neutral red phagocytosis assay, and the secretion of related cytokines.
View Article and Find Full Text PDFThe impact of white matter lesions and subclinical cerebral ischemia on postoperative cognitive training outcomes after heart valve surgery: A randomized clinical trial.
J Neurol Sci
December 2024
Heart and Brain Research Group, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany; Department of Neurology, University Hospital Giessen and Marburg, Giessen, Germany.
Background: White matter lesions and subclinical cerebral ischemia (SCI) are described as risk factors for postoperative cognitive decline (POCD) following cardiac surgery. This report aims to investigate the effect of brain lesions on postoperative cognitive training outcomes.
Methods: In a randomized, treatment-as-usual controlled trial, elderly patients scheduled for elective heart valve surgery participated.
Diagnosing progressive multifocal leukoencephalopathy: Positive predictive value of CSF JC virus quantitative PCR and importance of recognizing suggestive neuroimaging findings.
J Neurol Sci
January 2025
Department of Clinical Neurological Sciences, Western University, London Health Sciences Centre, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London Health Sciences Centre, London, Ontario, Canada. Electronic address:
Objective: To determine the positive predictive value (PPV) of CSF John Cunningham virus (JCV) quantitative PCR (qPCR) for progressive multifocal leukoencephalopathy (PML), and highlight neuroimaging findings reported to be suggestive of this disease.
Methods: We reviewed patients at London Health Sciences Centre with a positive CSF JCV qPCR result. Patients were classified as true-positive if they had a clinico-radiographic presentation compatible with PML and no more likely alternative diagnosis.
Utilizing metabolomic profiling as a supportive diagnostic tool for radiologically isolated syndrome.
Mult Scler Relat Disord
January 2025
Sancaktepe Prof.Dr.Ilhan Varank State Hospital, Neurology, Turkey.
Background: Radiologically Isolated Syndrome (RIS) characterized by abnormalities on MRI that do not manifest as clinical symptoms of Multiple Sclerosis (MS) but raise suspicion for MS. Considering that RIS often evolves into MS, various diagnostic criteria have been established, and each suggested biomarker warrants thorough consideration and discussion. In this study, metabolomic profiling of body fluids of patients who were being followed up with a pre-diagnosis of RIS or MS and had not yet received any treatment was conducted.
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