Colitis cystica profunda and solitary rectal ulcer syndrome-polyoid variant are related chronic benign disorders with characteristic histological features. However, the clinical and endoscopic settings are confusing and misleading, suggesting other rectal conditions. We report a case of colitis cystica profunda and solitary rectal ulcer syndrome-polypoid variant that was misdiagnosed initially as an ulcerative proctitis. Since an occult malignancy could not be ruled out by superficial biopsies, the mass was removed by full-thickness transanal excision.
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