AI Article Synopsis
- The study examined how different levels of TCDD, a toxic environmental compound, affect molar development in various strains of mice.
- Pregnant mice were exposed to TCDD at different doses, and their offspring were assessed for missing third molars and changes in the first molar's shape.
- Results showed that certain mouse strains experienced higher rates of missing molars with increased TCDD exposure, indicating genetic factors influence the impact of this toxicant on dental development.
Article Abstract
Objective: We evaluated the effects of different levels of the potent environmental toxicant and teratogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on molar development in mice in six inbred strains, all with TCDD responsive Ahr alleles.
Design: Pregnant females were exposed on gestation day 13 to 4 different levels of TCDD (control, 0.01, 0.1 and 1.0 microg/kg) and their offspring were examined for the frequency of missing third molars (M3s) and for differences in first mandibular molar (M1) cuspal morphology.
Results: Missing M3s were prevalent only in mice in two strains, C3H/HeJ and CBA/J, and their frequency significantly increased with increasing TCDD exposure. The frequency of the M1 variant was high in mice in only one strain, C57BL/10J, and was significantly higher in the treated compared with the control group.
Conclusions: Inbred mice strains exhibited differential responses to TCDD suggesting that there is a genetic component, beyond Ahr differences, mediating the effects of TCDD on molar development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916485 | PMC |
| http://dx.doi.org/10.1016/j.archoralbio.2006.10.017 | DOI Listing |
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