Objective: To examine the longitudinal construct validity and the responsiveness of the English and French versions of Qualiveen in multiple sclerosis (MS) patients with urinary disorders.
Design: Cohort study.
Setting: MS clinics and departments of rehabilitation in Canada and France.
Participants: One hundred eighty English-speaking and French-speaking outpatients who, at enrollment, were classified as "stable" if they had no urinary disorders requiring change in medicine, or "anticipated improvement" if they had troubling urinary disorders that mandated intensified treatment.
Interventions: Not applicable.
Main Outcome Measures: We tested predictions about the relation between changes in other questionnaires (Multiple Sclerosis Quality of Life-54 questionnaire or its French version, the SEP-59, and a global rating of change) and changes in the Qualiveen domains. A paired t test in the anticipated improvement group comparing scores before and after the intervention, and the magnitude of the standardized response mean (SRM) provided measures of responsiveness.
Results: Consistent with a priori predictions (weighted kappa=.71), changes in Qualiveen score correlated with changes in other questionnaires. All Qualiveen domains detected changes in patients in the anticipated improvement group (P<.001) and differentiated these patients from "stable" patients (P<.001);all SRMs were large (>.75).
Conclusions: Valid and responsive, both English and French versions are useful for MS studies into urinary disorders.
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http://dx.doi.org/10.1016/j.apmr.2006.08.345 | DOI Listing |
J Med Internet Res
January 2025
AIMS Lab, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Background: Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status is measured in clinical practice using paper-and-pencil tests, which are both time-consuming and costly. Remote monitoring of cognitive status could offer a solution because previous studies on telemedicine tools have proved its feasibility and acceptance among people with MS.
View Article and Find Full Text PDFJ Neurochem
January 2025
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Aging is the most common risk factor for Multiple Sclerosis (MS) disease progression. Cellular senescence, the irreversible state of cell cycle arrest, is the main driver of aging and has been found to accumulate prematurely in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Cellular senescence in the central nervous system of MS patients has recently gained attention, with several studies providing evidence that demyelination induces cellular senescence, with common hallmarks of p16INK4A and p21 expression, oxidative stress, and senescence-associated secreted factors.
View Article and Find Full Text PDFRev Esp Enferm Dig
January 2025
Hepatology. Gastroenterology Unit, Hospital Universitario Central de Asturias.
A 16-year-old boy was diagnosed from multiple sclerosis (MS) after suffering from paresthesia in upper limbs and VI cranial nerve paresis. Corticosteroids and fingolimod were started. After 13 months a worsening of liver biochemical tests (LBT) was noticed: ALP 787 U/L, GGT 737 U/L, AST 195, ALT 321, Bi 0.
View Article and Find Full Text PDFInt J Rehabil Res
January 2025
Department for the Rehabilitation of Patients After TBI, Multiple Sclerosis and Other Neurological Diseases, University Rehabilitation Institute, Linhartova cesta Ljubljana.
Acquired brain injuries can profoundly impact executive functioning, yet traditional neuropsychological assessments often have limitations, such as being time-intensive, lacking ecological validity, or failing to engage patients effectively. To address these challenges, CCRacer, a serious game, was developed as a novel tool for assessing executive functions in clinical populations. This study evaluated the convergent and discriminant validity of CCRacer by applying it alongside established neuropsychological tests to a sample of 78 participants with acquired brain injury.
View Article and Find Full Text PDFBr J Hosp Med (Lond)
December 2024
Department of Otolaryngology Head and Neck Surgery, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, China.
Tinnitus is a very common condition, and is a side effect of many medications. The panorama of drug-induced tinnitus has widened in recent decades, and post-marketing data are needed to gain a better insight into adverse drug reactions related to tinnitus. However, there are currently few studies on drug-induced tinnitus.
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