AI Article Synopsis
- Several key signaling pathways, including Hedgehog, Notch, Wnt, and BMP-TGFbeta-Activin, are vital for proper embryonic development and can contribute to tumor formation when reactivated in adults.
- The Hedgehog pathway, in particular, is often abnormally activated in basal cell carcinomas.
- Current research on the Hedgehog signaling pathway presents potential therapeutic opportunities for treating these skin cancers.
Article Abstract
Several key signalling pathways, such as Hedgehog, Notch, Wnt and BMP-TGFbeta-Activin (bone morphogenetic protein-transforming growth factor-beta-Activin), are involved in most processes essential to the proper development of an embryo. It is also becoming increasingly clear that these pathways can have a crucial role in tumorigenesis when reactivated in adult tissues through sporadic mutations or other mechanisms. We will focus here on the Hedgehog pathway, which is abnormally activated in most basal cell carcinomas, and discuss potential therapeutic opportunities offered by the progress made in understanding this signalling pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nrd2086 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of porous hedgehog-like morphology and graphene oxide on the cycling stability and rate performance of CoO/NiO microspheres.
Nanoscale Horiz
January 2025
Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Academy for Engineering & Technology, Advanced Coatings Research Center of Ministry of Education of China, Fudan University, Shanghai 200438, P. R. China.
A porous hedgehog-like CoO/NiO/graphene oxide (denoted as PHCNO/GO) microsphere was prepared by a facile solvothermal method, followed by an annealing treatment under argon atmosphere. Benefiting from the thin CoO/NiO nanosheets with a large specific surface area, abundant pores distributed between the CoO/NiO nanosheets, and GO firmly wrapped around the surface of PHCNO microspheres, the PHCNO/GO microspheres showed excellent lithium storage performance. The CoO/NiO nanosheets provided numerous active sites, achieving a high reversible specific capacity.
View Article and Find Full Text PDFMolecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer.
Int J Mol Sci
January 2025
Department of Biochemistry and Biophysics, "Carol Davila" University of Medicine and Pharmacy of Bucharest, 050474 Bucharest, Romania.
Cancer stem cells (CSC) are known to be the main source of tumor relapse, metastasis, or multidrug resistance and the mechanisms to counteract or eradicate them and their activity remain elusive. There are different hypotheses that claim that the origin of CSC might be in regular stem cells (SC) and, due to accumulation of mutations, these normal cells become malignant, or the source of CSC might be in any malignant cell that, under certain environmental circumstances, acquires all the qualities to become CSC. Multiple studies indicate that lifestyle and diet might represent a source of wellbeing that can prevent and ameliorate the malignant phenotype of CSC.
View Article and Find Full Text PDFMolecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review.
Cancers (Basel)
January 2025
School of Biotechnology, KIIT Deemed to Be University, Bhubaneswar 751024, India.
The complex signaling network within the breast tumor microenvironment is crucial for its growth, metastasis, angiogenesis, therapy escape, stem cell maintenance, and immunomodulation. An array of secretory factors and their receptors activate downstream signaling cascades regulating breast cancer progression and metastasis. Among various signaling pathways, the EGFR, ER, Notch, and Hedgehog signaling pathways have recently been identified as crucial in terms of breast cancer proliferation, survival, differentiation, maintenance of CSCs, and therapy failure.
View Article and Find Full Text PDFGPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.
J Exp Clin Cancer Res
January 2025
Department of Neurosurgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms regarding OC carcinogenesis and discovery of novel targets is of great importance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!