Catechol and pyrogallol are allelochemicals which belong to phenolic compounds synthesized in plants. Their antimicrobial activities were investigated on three bacteria (Pseudomonas putida, Pseudomonas pyocyanea, Corynebacterium xerosis) and two fungi (Fusarium oxysporum, Penicillium italicum) phytopathogenic species as test organisms using the disc diffusion method. Both catechol and pyrogallol were found to have antibacterial effects on all the bacteria used in the study at 5 and 10 mM concentrations. Catechol has also been found to have an antifungal effect on the fungi used in the study, whereas no antifungal effects of pyrogallol were observed. The most sensitive species among the bacteria was P. putida which was inhibited by the allelochemicals even at 1 mM concentration.
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http://dx.doi.org/10.1515/znc-2006-9-1004 | DOI Listing |
Microorganisms
January 2025
State Key Laboratory of Microbial Technology and Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Phenolic compounds are industrially versatile chemicals that have been successfully produced in microbial cell factories. Unfortunately, most phenolic compounds are highly toxic to cells in specific cellular environments or above a particular concentration because they form a complex with iron and promote hydroxyl radical production in Fenton reactions, resulting in the ferroptosis of cells. Here, we demonstrated that overexpression of efflux pumps and porins, including porins LamB and OmpN, and efflux pumps EmrAB, MdtABC, and SrpB, can enhance phloroglucinol (PG) tolerance by inhibiting the generation of hydroxyl radicals.
View Article and Find Full Text PDFMolecules
December 2024
Department of Solid State Chemistry, University of Chemistry and Technology, Prague, Technicka 5, 16628 Prague, Czech Republic.
Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates the cocrystallization of APR with four phenolic-type coformers: phenol, catechol, pyrogallol, and hydroxyquinol.
View Article and Find Full Text PDFAntioxidants (Basel)
December 2024
Escuela de Alimentos, Pontificia Universidad Católica de Valparaíso, Waddington 716, Playa Ancha, Valparaíso 2360100, Chile.
Boldo ( M.), an plant endemic to central and southern Chile, has been recognized as a medicinal herb, especially its leaves that are rich in bioactive compounds with beneficial properties, such as antioxidant, anti-inflammatory, sedative, and antimicrobial properties, among others. This research aimed to evaluate solid-liquid extraction using a response surface methodology to obtain phenolic-rich extracts from boldo leaves and to encapsulate them through spray-drying.
View Article and Find Full Text PDFAdv Healthc Mater
December 2024
Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Muscle atrophy detrimentally impacts health and exacerbates physical disability, leading to increased mortality. In particular, sarcopenia, aging-related degenerative muscle loss, necessitates urgent remedies. Current approaches for treating muscle atrophy include exercise and nutrition, while drug exploration remains in its early stages.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China. Electronic address:
Acrolein (ACR) is a widespread, highly toxic substance that poses significant health risks. Flavonoids have been recognized as effective ACR scavengers, offering a possible way to reduce these risks. However, the lack of specific high-throughput screening methods has limited the identification of ACR scavengers, and their actual detoxifying capacity on ACR remains unknown.
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