Purpose: The purpose of this study was to investigate changes that occur in pulmonary function when postural changes in the sagittal plane are made in a seated position in patients diagnosed with chronic obstructive pulmonary disease (COPD).
Methods: Fourteen patients diagnosed with COPD participated in this study. Standard spirometric measurements (minute ventilation, forced vital capacity, and forced expiratory volume in 1 second) were taken for each patient in each of 2 sitting postures: slumped and upright. Breathing frequency, heart rate, and blood oxygen saturation were also recorded for each of the 2 postures. Patients assumed each posture for 5 minutes before any measurements were taken, after which measurements were recorded each minute for an additional 5 minutes.
Results: A 2-factor (posture and time) analysis of variance with repeated measures on both factors was used to analyze the data. There were no significant differences between the means for heart rate, blood oxygen saturation, and breathing frequency. Paired t tests likewise did not reveal any significant differences between the slumped and upright positions for forced expiratory volume in 1 second, forced vital capacity, and minute ventilation.
Conclusions: These results suggest that there are no differences in measures of pulmonary function (minute ventilation, forced vital capacity, and forced expiratory volume in 1 second) and breathing frequency, heart rate, and blood oxygen saturation between slumped and upright sitting in patients with COPD. Based on this evidence alone, it may be inappropriate to instruct a patient with COPD to sit upright to improve respiratory function. However, further study is warranted before any definite recommendations can be made regarding sitting posture and respiratory performance in individuals with COPD.
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http://dx.doi.org/10.1097/00008483-200611000-00011 | DOI Listing |
PLoS Pathog
January 2025
Graduate Program in Immunology, Ann Arbor, Michigan, United States of America.
Neutrophils play key protective roles in influenza infections, yet excessive neutrophilic inflammation is a hallmark of acute lung injury during severe infections. Phenotypic heterogeneity is increasingly recognized in neutrophil populations; however, how functional variation in neutrophils between individuals determine the diverse outcomes of influenza remains unclear. To examine immunologic responses that may drive varying outcomes in influenza, we infected C57BL/6 (B6) and A/J mice with mouse-adapted influenza A virus A/PR/8/34 H1N1.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Aim: To comprehensively investigate the effects of antioxidant nutrients on muscle mass, strength and function in chronic obstructive pulmonary disease (COPD) patients.
Methods: PubMed, Embase, Cochrane Library, and Web of Science were comprehensively searched from the inception to January 3, 2024. The quality of randomized controlled trials (RCTs) was measured using the Jadad scale.
PLoS One
January 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Introduction: Haemodynamic atrioventricular delay (AVD) optimisation has primarily focussed on signals that are not easy to acquire from a pacing system itself, such as invasive left ventricular catheterisation or arterial blood pressure (ABP). In this study, standard clinical central venous pressure (CVP) signals are tested as a potential alternative.
Methods: Sixteen patients with a temporary pacemaker after cardiac surgery were studied.
J Cell Mol Med
January 2025
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
The pathogenesis of chronic thromboembolic pulmonary hypertension may be multifactorial and requires further studies. We explored alterations in pulmonary artery endothelial cells under the hypoxic and elevated interleukin-17 conditions that are commonly present in patients with chronic thromboembolic pulmonary hypertension. We measured the serum interleukin-17 levels in 10 chronic thromboembolic pulmonary hypertension patients and 10 healthy control persons.
View Article and Find Full Text PDFStem Cells Transl Med
January 2025
Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.
Disruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic hernia (CDH) and oligohydramnios. Both entities have high morbidity and mortality, and no effective therapy that fully restores normal lung development.
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