Nonenzymatic oligomerization of RNA by TNA templates.

Org Lett

Department of Chemistry, University of California, Riverside, CA 92521, USA.

Published: December 2006

Cytosine TNA promotes nonenzymatic, template-directed oligomerization of complementary activated rGMP, leading to selective and efficient formation of RNA products. This process models "genetic takeover" of a pre-RNA by RNA. [reaction: see text]

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Source
http://dx.doi.org/10.1021/ol062368sDOI Listing

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