A series of rigid linear and star-shaped pi-conjugated 2,2':6',2"-terpyridine derivatives with the C-C single-, double-, and triple-bond linkages have been developed through the Suzuki, the Sonogashira, and the Wittig reactions. Such large rigid ligands exhibit strong blue emission in dilute solutions. [structure: see text]
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http://dx.doi.org/10.1021/ol0621405 | DOI Listing |
Comput Struct Biotechnol J
December 2024
School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong 250300, China.
Protein circular permutations are crucial for understanding protein evolution and functionality. Traditional detection methods face challenges: sequence-based approaches struggle with detecting distant homologs, while structure-based approaches are limited by the need for structure generation and often treat proteins as rigid bodies. Protein Language Model-based alignment tools have shown advantages in utilizing sequence information to overcome the challenges of detecting distant homologs without requiring structural input.
View Article and Find Full Text PDFMolecules
January 2025
Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA.
Optically responsive materials are applied in sensing, actuators, and optical devices. One such class of material is dye-doped liquid crystal polymers that self-assemble into cholesteric mesophases that reflect visible light. We report here the synthesis and characterization of a family of linear and mildly crosslinked terpolymers prepared by the ROMP of norbornene-based monomers.
View Article and Find Full Text PDFLife (Basel)
December 2024
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA.
Background: This study aimed to explore the potential associations between voice metrics of patients with PD and their motor symptoms.
Methods: Motor and vocal data including the Unified Parkinson's Disease Rating Scale part III (UPDRS-III), Harmonic-Noise Ratio (HNR), jitter, shimmer, and smoothed cepstral peak prominence (CPPS) were analyzed through exploratory correlations followed by univariate linear regression analyses. We employed these four voice metrics as independent variables and the total and sub-scores of the UPDRS-III as dependent variables.
Biosensors (Basel)
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210092, China.
Herein, a sensitive electrochemiluminescence (ECL) immunosensor is designed by immobilizing ruthenium-tagged immune complexes at flexible poly-ethylene-glycol (PEG) chains on the electrode surface, which offers more freedom for the collision of the ruthenium complex at the electrode during the initial ECL reaction. The electrochemical characterizations confirm the loose structure of the assembled layer with the immune complex, providing an increase in the current and the resultant enhanced ECL emissions. Comparing the sensors with the rigid structure, a 34-fold increase in the maximal ECL emission is recorded when PEG3400 is used as a linker.
View Article and Find Full Text PDFJ Orthop
August 2025
University of Alabama at Birmingham, Department of Orthopaedic Surgery, Birmingham, AL, USA.
Purpose: This study aims to compare the biomechanical performance of elastic and static suture-based cerclage systems to traditional screw constructs in the setting of modeled glenoid bony augmentation.
Methods: Biomechanical testing was conducted on polyurethane cellular foam blocks modeling a 20 % glenoid defect repaired with a coracoid graft. Constructs consisted of an elastic suture-based cerclage, static suture-based cerclage, and a two-screw construct.
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