[The modulation of the interferon system by gamma-globulin preparations].

Preparations of specific and commercial gamma-globulin against hepatitis A virus caused a marked inhibition of alpha- and gamma-links of the IF system 7 days after administration. In 80% of the subjects given commercial gamma-globulin 14 days after administration the above values returned to those observed before administration of the preparations. The recovery of the leukocyte capacity for alpha-IF production after administration of specific gamma-globulin was observed only in 50% of the subjects examined, while inhibition of the gamma-link of IF system persisted for 14 days (50%) or showed a poor trend to restoration not reaching the initial levels.