AI Article Synopsis
- RNA damage has not been extensively studied in biomedical research, and its causes and effects are still mostly unknown.
- Recent findings indicate that RNA integrity loss and oxidative modifications (like 8-oxoG) are common in advanced atherosclerotic plaques, potentially due to factors like oxidative stress and iron deposition.
- This RNA damage could destabilize atherosclerotic plaques, possibly leading to their rupture and affecting gene expression data by interfering with transcript quantification.
Article Abstract
RNA damage is a poorly examined field in biomedical research. Potential triggers of RNA damage as well as its pathophysiological implications remain largely unknown. Here we summarize recent evidence that loss of RNA integrity and 7,8-dihydro-8-oxo-2'-guanosine (8-oxoG) oxidative RNA modifications frequently occur in advanced human atherosclerotic plaques. At least two features of advanced human plaques, namely oxidative stress and intraplaque hemorrhage followed by iron deposition, may be involved in the process of RNA degradation. Although speculative, RNA damage may lead to destabilization and rupture of atherosclerotic plaques by interfering with protein synthesis and stimulation of cell death. Moreover, RNA damage may affect in vitro transcript quantification, thereby influencing data from gene expression studies.
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| http://dx.doi.org/10.4161/rna.2.1.1430 | DOI Listing |
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